How Divesiran Works
Divesiran is an investigational siRNA therapy that works by "silencing" the TMPRSS6 gene. Silencing TMPRSS6 lifts the natural brake on hepcidin - the body's master iron regulator. When TMPRSS6 is turned down, hepcidin levels rise, which reduces how much iron the body absorbs and releases into the bloodstream. Since iron is the key ingredient needed to make red blood cells, having less of it slows down the excessive red blood cell production seen in PV. This helps keep hematocrit levels in a safer range and can reduce the need for frequent phlebotomies.