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At Silence, our vision is to transform peoples’ lives around the world by silencing diseases through our precision engineered medicines and driving positive change for the communities around us.

Our investigational product candidates harness the body's natural mechanism of RNA interference (RNAi) to precisely target and silence disease-associated genes.

Learn How Gene Silencing Works

To drive deeper understanding of what it is like to live with rare diseases like Thalassemia and Polycythemia Vera, as well as educate on the value of gene silencing as a potential treatment for rare diseases, we have developed the coloring book below.

Download a copy here and share your coloring with us using #SilenceRareDisease #ShareYourColors

Thank you to our partners MPN Alliance, MPN Voice and UKTS for your input and collaboration.


Our Clinical Trials

We are currently conducting clinical trials for cardiovascular disease due to high levels of lipoprotein(a), or Lp(a), and thalassemia.

APOLLO 360

Learn More About the ALPACAR-360 Phase 2 Clinical Program in Participants with Elevated Lipoprotein(a) at High Risk of Atherosclerotic Cardiovascular Disease Events

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gemini

Learn More About the GEMINI II Phase 1 Clinical Program for Thalassemia

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To support better understanding of the diseases we are currently researching, we have developed a series of ‘eBooks’ to provide an overview of their impact and current management approaches.