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Our Global Vision

At Silence, we aim to transform peoples’ lives around the world by silencing diseases through our precision engineered medicines and driving positive change for the communities around us. As pioneers in the design and development of siRNAs (short interfering RNAs), we are advancing a new generation of medicines to potentially address the needs of patients who have limited or inadequate treatment options.

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Our mRNAi GOLD™ Platform

Our proprietary mRNAi GOLD™ platform consists of precision engineered product candidates designed to accurately target and 'silence' specific disease associated genes in the liver by using the body's natural process of RNAi (RNA interference). Through this approach, we are advancing a robust pipeline of wholly owned and partnership programs for diseases with high unmet need.

  • natural


    Harnesses natural mechanisms present in every cell in the human body

  • durable


    Long-lasting gene silencing possible following a single injection

  • precise


    siRNA designed to bind only to the target gene



Pipeline Programs


In Clinical Trials


Wholly Owned


Strategic Collaborations

Our Commitment to Patients

We see the patient in every action. Their needs drive our discoveries and relentless commitment to deliver life-changing therapies as efficiently as possible. We know that patients are waiting and that responsibility inspires us to do our best every day.


Join a Great Place to Work®

We’re a vibrant, growing, global company with a start-up mindset. One that begins with doing what we love and ends with fulfilling our vision. We’re seeking smart, fun and passionate people to join our expanding team.