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microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) and represent two classes of important non-coding RNAs in eukaryotes. Although these non-coding RNAs have been implicated in organismal development and in various human diseases, surprisingly little is known about their transcriptional regulation. Recent advances in chromatin immunoprecipitation with next-generation DNA sequencing (ChIP-Seq)... Contine Reading & Discuss→
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The miREC database (miRNAs involved in Endometrial Cancer) combines published data about miRNAs and genes deregulated in endometrial cancer, as well as target-regulator relationships between these genes and miRNAs. All information has been extracted from published literature and entries are supplemented by reference citations.
The miREC database was launched in... Contine Reading & Discuss→
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With two miRNA conferences coming up that focus on this field I thought the following manually curated database will be useful: miRandola.
Extracellular miRNAs in serum, plasma, saliva, urine and other body fluids have recently been shown to be associated with various pathological conditions including cancer. miRNAs circulate in the... Contine Reading & Discuss→
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In order to better understand microRNAs of interest it is of utmost importance to learn about the genomic conservation of these genes. The miRviewer web-server encompasses all known (and some novel) microRNAs of currently fully annotated animal genomes in a visual ‘birds-eye’ view representation. miRviewer provides a graphical outlook of... Contine Reading & Discuss→
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Single nucleotide polymorphisms (SNPs) can lead to the susceptibility and onset of diseases through their effects on gene expression at the posttranscriptional level. Recent findings indicate that SNPs could create, destroy, or modify the efficiency of miRNA binding to the 3′UTR of a gene, resulting in gene dysregulation. With the... Contine Reading & Discuss→
