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Tag Archives: PLoS Genet

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  • Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis.

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    May 04, 2013

    Scavenger Receptors Mediate the Role of SUMO and Ftz-f1 in Drosophila Steroidogenesis. PLoS Genet. 2013 Apr;9(4):e1003473 Authors: Talamillo A, Herboso L, Pirone L, Pérez C, González M, Sánchez J, Mayor U, Lopitz-Otsoa F, Rodriguez MS, Sutherland JD, Barrio R Abstract SUMOylation participates in ecdysteroid biosynthesis at the onset of metamorphosis... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • Identification of a tissue-selective heat shock response regulatory network.

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    Identification of a tissue-selective heat shock response regulatory network. PLoS Genet. 2013 Apr;9(4):e1003466 Authors: Guisbert E, Czyz DM, Richter K, McMullen PD, Morimoto RI Abstract The heat shock response (HSR) is essential to survive acute proteotoxic stress and has been studied extensively in unicellular organisms and tissue culture cells, but... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • Surveillance-Activated Defenses Block the ROS-Induced Mitochondrial Unfolded Protein Response.

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    March 22, 2013

    Related Articles Surveillance-Activated Defenses Block the ROS-Induced Mitochondrial Unfolded Protein Response. PLoS Genet. 2013 Mar;9(3):e1003346 Authors: Runkel ED, Liu S, Baumeister R, Schulze E Abstract Disturbance of cellular functions results in the activation of stress-signaling pathways that aim at restoring homeostasis. We performed a genome-wide screen to identify components of... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • RNAi-Based Functional Profiling of Loci from Blood Lipid Genome-Wide Association Studies Identifies Genes with Cholesterol-Regulatory Function.

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    March 08, 2013

    RNAi-Based Functional Profiling of Loci from Blood Lipid Genome-Wide Association Studies Identifies Genes with Cholesterol-Regulatory Function. PLoS Genet. 2013 Feb;9(2):e1003338 Authors: Blattmann P, Schuberth C, Pepperkok R, Runz H Abstract Genome-wide association studies (GWAS) are powerful tools to unravel genomic loci associated with common traits and complex human disease. However,... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans.

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    Roles of the Developmental Regulator unc-62/Homothorax in Limiting Longevity in Caenorhabditis elegans. PLoS Genet. 2013 Feb;9(2):e1003325 Authors: Van Nostrand EL, Sánchez-Blanco A, Wu B, Nguyen A, Kim SK Abstract The normal aging process is associated with stereotyped changes in gene expression, but the regulators responsible for these age-dependent changes are... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target.

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    A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target. PLoS Genet. 2013 Feb;9(2):e1003313 Authors: Saur T, Demarco SE, Ortiz A, Sliwoski GR, Hao L, Wang X, Cohen BM, Buttner EA Abstract We report a genome-wide RNA interference (RNAi) screen for... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • A regulatory pathway, ecdysone-transcription factor relish-cathepsin L, is involved in insect fat body dissociation.

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    March 07, 2013

    A regulatory pathway, ecdysone-transcription factor relish-cathepsin L, is involved in insect fat body dissociation. PLoS Genet. 2013 Feb;9(2):e1003273 Authors: Zhang Y, Lu YX, Liu J, Yang C, Feng QL, Xu WH Abstract Insect fat body is the organ for intermediary metabolism, comparable to vertebrate liver and adipose tissue. Larval fat... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma.

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    A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma. PLoS Genet. 2013 Feb;9(2):e1003253 Authors: Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee WK, Mischel PS, Furnari FB, Thomas... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells.

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    January 05, 2013

    Related Articles A Synthetic Interaction Screen Identifies Factors Selectively Required for Proliferation and TERT Transcription in p53-Deficient Human Cancer Cells. PLoS Genet. 2012 Dec;8(12):e1003151 Authors: Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM, Green MR Abstract Numerous genetic... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 
  • ATX1-Generated H3K4me3 Is Required for Efficient Elongation of Transcription, Not Initiation, at ATX1-Regulated Genes.

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    Related Articles ATX1-Generated H3K4me3 Is Required for Efficient Elongation of Transcription, Not Initiation, at ATX1-Regulated Genes. PLoS Genet. 2012 Dec;8(12):e1003111 Authors: Ding Y, Ndamukong I, Xu Z, Lapko H, Fromm M, Avramova Z Abstract Tri-methylated H3 lysine 4 (H3K4me3) is associated with transcriptionally active genes, but its function in the... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  PLoS Genet | 

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