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Tag Archives: Genes Dev

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  • Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A.

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    May 10, 2013

    Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A. Genes Dev. 2013 May 1;27(9):1032-45 Authors: Hubert CG, Bradley RK, Ding Y, Toledo CM, Herman J, Skutt-Kakaria K, Girard EJ, Davison J, Berndt J, Corrin P, Hardcastle J, Basom R, Delrow JJ, Webb T, Pollard... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

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    April 21, 2013

    Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev. 2013 Apr 18; Authors: DeschĂȘnes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G Abstract Constitutive activation of growth factor... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression.

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    February 10, 2013

    Related Articles Two new and distinct roles for Drosophila Argonaute-2 in the nucleus: alternative pre-mRNA splicing and transcriptional repression. Genes Dev. 2013 Feb 7; Authors: Taliaferro JM, Aspden JL, Bradley T, Marwha D, Blanchette M, Rio DC Abstract Transcription and pre-mRNA alternative splicing are highly regulated processes that play major... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.

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    January 18, 2013

    Related Articles Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target. Genes Dev. 2013 Jan 15; Authors: Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J,... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway.

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    Related Articles Homologous recombination as a mechanism to recognize repetitive DNA sequences in an RNAi pathway. Genes Dev. 2013 Jan 15; Authors: Zhang Z, Chang SS, Zhang Z, Xue Z, Zhang H, Li S, Liu Y Abstract Quelling is an RNAi-related phenomenon that post-transcriptionally silences repetitive DNA and transposons in... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila.

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    November 17, 2012

    Related Articles CLOCK deubiquitylation by USP8 inhibits CLK/CYC transcription in Drosophila. Genes Dev. 2012 Nov 15;26(22):2536-49 Authors: Luo W, Li Y, Tang CH, Abruzzi KC, Rodriguez J, Pescatore S, Rosbash M Abstract A conserved transcriptional feedback loop underlies animal circadian rhythms. In Drosophila, the transcription factors CLOCK (CLK) and CYCLE... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.

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    September 19, 2012

    Related Articles Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells. Genes Dev. 2012 Sep 15;26(18):2015-26 Authors: Clippinger AJ, Alwine JC Abstract Activation of stress signaling pathways normally leads to inhibition of the mammalian target of rapamycin complex 1 (mTORC1); however, human cytomegalovirus (HCMV) infection... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3′ end modification.

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    August 18, 2012

    C16orf57, a gene mutated in poikiloderma with neutropenia, encodes a putative phosphodiesterase responsible for the U6 snRNA 3' end modification. Genes Dev. 2012 Aug 16; Authors: Mroczek S, Krwawicz J, Kutner J, Lazniewski M, Kucinski I, Ginalski K, Dziembowski A Abstract C16orf57 encodes a human protein of unknown function, and... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena.

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    August 03, 2012

    Biased transcription and selective degradation of small RNAs shape the pattern of DNA elimination in Tetrahymena. Genes Dev. 2012 Aug 1;26(15):1729-42 Authors: Schoeberl UE, Kurth HM, Noto T, Mochizuki K Abstract The ciliated protozoan Tetrahymena undergoes extensive programmed DNA elimination when the germline micronucleus produces the new macronucleus during sexual... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 
  • MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline.

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    June 21, 2012

    Related Articles MUT-16 promotes formation of perinuclear Mutator foci required for RNA silencing in the C. elegans germline. Genes Dev. 2012 Jun 19; Authors: Phillips CM, Montgomery TA, Breen PC, Ruvkun G Abstract RNA silencing can be initiated by endogenous or exogenously delivered siRNAs. In Caenorhabditis elegans, RNA silencing guided... Contine Reading & Discuss→

    Posted in :  News |  Other News |  Publications |  Syndicated |  Tagged in :  Genes Dev | 

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