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Tag Archives: Blood

• LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK cell cytotoxicity.

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  May 03, 2013

  LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK cell cytotoxicity. Blood. 2013 Apr 30; Authors: Krzewski K, Gil-Krzewska A, Nguyen V, Peruzzi G, Coligan JE Abstract Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are indispensable for NK cell cytotoxicity, as their release... Contine Reading & Discuss→

• Exosome Presents Late-Breaking Study Demonstrating Ability to Profile RNA from Archived Clinical Trial Blood Samples at 2013 AACR Anual Meeting

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  April 08, 2013

  NEW YORK, April 8, 2013 /PRNewswire/ – Exosome Diagnostics, a leading developer of biofluid-based molecular diagnostics for use in personalized medicine, today announced that the company is presenting a late-breaking abstract at the AACR Annual Meeting 2013, in Washington D.C.  The abstract is titled “Exosome profiling of mRNAs and miRNAs in... Contine Reading & Discuss→

• RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model.

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  February 28, 2013

  RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. Blood. 2013 Feb 25; Authors: Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J Abstract ABT-737 is a promising chemotherapeutic agent... Contine Reading & Discuss→

• Non-redundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells.

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  January 27, 2013

  Non-redundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells. Blood. 2013 Jan 24; Authors: van den Boom V, Rozenveld-Geugien M, Bonardi F, Malanga D, van Gosliga D, Heijink AM, Viglietto G, Morrone G, Fusetti F, Vellenga E, Schuringa JJ Abstract The Polycomb group... Contine Reading & Discuss→

• Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex.

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  January 06, 2013

  Targeting transcription factor SALL4 in acute myeloid leukemia by interrupting its interaction with an epigenetic complex. Blood. 2013 Jan 3; Authors: Gao C, Dimitrov T, Yong KJ, Tatetsu H, Jeong HW, Luo HR, Bradner JE, Tenen DG, Chai L Abstract An exciting recent approach to target transcription factors in cancer... Contine Reading & Discuss→

• Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition.

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  September 08, 2012

  Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition. Blood. 2012 Sep 5; Authors: Cea M, Cagnetta A, Fulciniti M, Tai YT, Hideshima T, Chauhan D, Roccaro A, Sacco A, Calimeri T, Cottini F, Jakubikova J, Kong SY, Patrone F, Nencioni... Contine Reading & Discuss→

• Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion and capillary formation.

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  August 18, 2012

  Tyrosine phosphorylation of DEP-1/CD148 as a mechanism controlling Src kinase activation, endothelial cell permeability, invasion and capillary formation. Blood. 2012 Aug 16; Authors: Spring K, Chabot C, Langlois S, Lapointe L, Trinh NT, Caron C, Hebda JK, Gavard J, Elchebly M, Royal I Abstract DEP-1/CD148 is a receptor-like protein tyrosine... Contine Reading & Discuss→

• Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1.

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  June 12, 2012

  Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1. Blood. 2012 Jun 8; Authors: Fang J, Rhyasen G, Bolanos L, Rasch C, Varney M, Wunderlich M, Goyama S, Jansen G, Cloos J, Rigolino C, Cortelezzi A, Mulloy JC, Oliva... Contine Reading & Discuss→

• RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion.

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  May 06, 2012

  RNAi screen identifies MAPK14 as a druggable suppressor of human hematopoietic stem cell expansion. Blood. 2012 May 3; Authors: Baudet A, Karlsson C, Safaee Talkhoncheh M, Galeev R, Magnusson M, Larsson J Abstract We report on a forward RNAi screen in primary human hematopoietic stem and progenitor cells, using pooled... Contine Reading & Discuss→