Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNAi-mediated silencing in mammalian cells. Mol Biol Cell. 2013 Jun 5; Authors: Pare JM, Lapointe P, Hobman TC Abstract Argonaute proteins and small RNAs together form the RNA-induced silencing complex (RISC), the central effector of RNA interference (RNAi). The...Contine Reading & Discuss→
RNAi HubWelcome to Silence Therapeutics’ RNAi Hub. The RNAi Hub features the latest national and international news and advances in the development and delivery of RNAi therapeutics. As a leader in the discovery and development of gene silencing technology in the treatment of serious diseases, the Silence Therapeutics’ RNAi Hub keeps you up to date with the latest news, articles and publications on related topics as RNA interference, RNAi technology and siRNA technology.
SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells. Cell Physiol Biochem. 2013 May 31;31(6):778-784 Authors: Cui Y, Chen J, He Z, Xiao Y Abstract Background/Aims: SUZ12 and EZH2 are two main components of polycomb repressive complex 2 (PRC2) that is known to be of great importance in tumorigenesis. EZH2...Contine Reading & Discuss→
Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA. Mol Ther Nucleic Acids. 2013;2:e96 Authors: McCaskill J, Singhania R, Burgess M, Allavena R, Wu S, Blumenthal A, McMillan NA Abstract RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However,...Contine Reading & Discuss→
Biases in the experimental annotations of protein function and their effect on our understanding of protein function space. PLoS Comput Biol. 2013 May;9(5):e1003063 Authors: Schnoes AM, Ream DC, Thorman AW, Babbitt PC, Friedberg I Abstract The ongoing functional annotation of proteins relies upon the work of curators to capture experimental...Contine Reading & Discuss→
Production of cloned pigs with targeted attenuation of gene expression. PLoS One. 2013;8(5):e64613 Authors: Bordignon V, El-Beirouthi N, Gasperin BG, Albornoz MS, Martinez-Diaz MA, Schneider C, Laurin D, Zadworny D, Agellon LB Abstract The objective of this study was to demonstrate that RNA interference (RNAi) and somatic cell nuclear transfer...Contine Reading & Discuss→