RNAi Hub

• Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNAi-mediated silencing in mammalian cells.

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  June 08, 2013

  Hsp90 cochaperones p23 and FKBP4 physically interact with hAgo2 and activate RNAi-mediated silencing in mammalian cells. Mol Biol Cell. 2013 Jun 5; Authors: Pare JM, Lapointe P, Hobman TC Abstract Argonaute proteins and small RNAs together form the RNA-induced silencing complex (RISC), the central effector of RNA interference (RNAi). The...

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• SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells.

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  June 07, 2013

  SUZ12 Depletion Suppresses the Proliferation of Gastric Cancer Cells. Cell Physiol Biochem. 2013 May 31;31(6):778-784 Authors: Cui Y, Chen J, He Z, Xiao Y Abstract Background/Aims: SUZ12 and EZH2 are two main components of polycomb repressive complex 2 (PRC2) that is known to be of great importance in tumorigenesis. EZH2...

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• Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA.

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  Efficient Biodistribution and Gene Silencing in the Lung epithelium via Intravenous Liposomal Delivery of siRNA. Mol Ther Nucleic Acids. 2013;2:e96 Authors: McCaskill J, Singhania R, Burgess M, Allavena R, Wu S, Blumenthal A, McMillan NA Abstract RNA interference (RNAi) may provide a therapeutic solution to many pulmonary epithelium diseases. However,...

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• Biases in the experimental annotations of protein function and their effect on our understanding of protein function space.

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  Biases in the experimental annotations of protein function and their effect on our understanding of protein function space. PLoS Comput Biol. 2013 May;9(5):e1003063 Authors: Schnoes AM, Ream DC, Thorman AW, Babbitt PC, Friedberg I Abstract The ongoing functional annotation of proteins relies upon the work of curators to capture experimental...

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• Production of cloned pigs with targeted attenuation of gene expression.

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  Production of cloned pigs with targeted attenuation of gene expression. PLoS One. 2013;8(5):e64613 Authors: Bordignon V, El-Beirouthi N, Gasperin BG, Albornoz MS, Martinez-Diaz MA, Schneider C, Laurin D, Zadworny D, Agellon LB Abstract The objective of this study was to demonstrate that RNA interference (RNAi) and somatic cell nuclear transfer...

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