Corporate Governance

In accordance with AIM Rule 26, Silence Therapeutics plc offers the following information:

Countries of Registration:

England and Wales

Company Registered Number:

2992058

Location of Operations:

Silence is headquartered in the U.K. with research and development operations carried out in Germany.

Nominated Advisors and Brokers:

Singer Capital Markets Limited 1 Hanover Street London W1S 1YZ Tel: +44 20 3205 7500

Constitutional Documents:

Disclosure Forms:

Meeting Notification and Proxy:

Annual and Interim Reports:

Recent Circulars:

Fundraising Presentations:

Committee Composition:

Remuneration Committee – Assisting the board in the discharging of its responsibilities related to remuneration of the company’s executive officers.

    • Annette Clancy (Chairman)
    • Jerry Randall
 
  • David Mack


Audit Committee – Assisting board oversight of accounting and financial reporting processes and the audits of the company’s financial statements

    • Jerry Randall (Chairman)
 

Nominations and Governance Committee – Recommending to the board those persons to be nominated for election as directors at any shareholders meeting

  • Annette Clancy
  • David Mack
 

Major Shareholdings

As at 31 March 2012 the Company had been informed of the following substantial interests of over 3% of the issued share capital of the Company:
Name Number Percentage of Issued Share Capital
Robert Keith* 54,089,628 9.37%
Hedger Management 50,000,000 8.66%
Frazier Healthcare Ventures 27,265,465 4.72%
Richard Bernstein 26,515,000 4.59%
Southern Fox Investments 26,173,913 4.54%
ACP Capital 25,356,422 4.39%
Simpson Financial 25,000,000 4.33%
Walker Crips Stockbrokers 24,257,101 4.20%
In addition to the direct holdings above Robert Keith has an indirect interest in a further 13m shares

Issued shares:

Number of securities in issue: 577,114,517 ordinary shares