About Us

Silence Therapeutics is a leading RNA technology company.

We have our own proprietary delivery systems which, combined with our RNA technology, enable the development of multiple products. This allows the development of therapeutics for diseases with high unmet medical need.

Silence is one of very few listed companies globally with human validated RNA delivery technology. This AtuRNAi® technology is one of the safest and most tested, with over 400 patients dosed and no immune response observed so far. It has been used in three Phase 2 clinical trials, two awaiting results. It also has a robust IP estate protecting its proprietary technology.

What is RNA interference?

RNA (ribonucleic acid) is one of the two types of nucleic acids found in all cells – the other being DNA (deoxyribonucleic acid). RNA is the messenger that takes a copy of the genetic information stored in DNA in a cell’s nucleus and translates it into instructions for the manufacture of proteins in that cell.

RNA interference (RNAi) is a method of reducing or ‘silencinggene expression. It is a naturally occurring phenomenon which can be used to selectively turn down the genes which cause some diseases. Genes are the blueprints for proteins, the building blocks of life, and this technology can selectively silence potentially any gene in the genome, preventing the overexpression of that gene and reducing the production of disease-causing proteins.

The ability to specifically target these proteins could open the door to types of therapeutics that current treatments such as small molecules and antibodies cannot address.

Take a look at our ‘Introduction to RNA interference’ video here.

Capital Markets Presentation – 1 December 2014